YARS2

Across TCGA cell cohorts, YARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,100 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible YARS2-associated GO terms across cancer lineages are Amino acid activation, tRNA aminoacylation, and Mitochondrial gene expression. Each is linked with YARS2 in more than 13 cancer types. Because this analysis shows association rather than direction, both YARS2-to-partner and partner-to-YARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino acid activation grouped by YARS2-low versus YARS2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS2→partner) and Y-score (partner→YARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Amino acid activation →	+0.103	+0.667	.002	.003	2	14
LIVER	tRNA aminoacylation →	+0.103	+0.667	.002	.003	2	14
BREAST	Mitochondrial gene expression →	+0.086	+0.647	<.001	<.001	3	13
LUNG_SCLC	RNA modification →	+0.051	+0.683	.003	.009	3	13
LIVER	Maturation of SSU-rRNA →	+0.119	+0.746	.002	.001	3	12
BONE	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.140	+0.450	.008	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,100 associations by consensus.

Amino acid activation by YARS2 expression — LIVER

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