YARS1

Across TCGA patient cohorts, YARS1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YARS1-associated genes across cancer lineages are FoxM1, Ku80, and Notch1. Each is linked with YARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YARS1-to-partner and partner-to-YARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by YARS1-low versus YARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS1→partner) and Y-score (partner→YARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.236	+1.847	.012	.008	3	2
UCEC	Ku80 →	+0.207	+1.515	.017	.018	3	2
UCEC	Notch1 →	+0.205	+1.847	<.001	.008	3	2
UCEC	p62 Lck ligand →	+0.451	+2.736	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.496	-2.492	<.001	.001	3	2
UCEC	ASNS →	+0.358	+1.874	.007	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FoxM1 by YARS1 expression — UCEC

Explore this box plot interactively →