YARS1

Across TCGA cell cohorts, YARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,176 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YARS1-associated GO terms across cancer lineages are Formate biosynthetic process, tRNA transport, and L-amino acid biosynthetic process. Each is linked with YARS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both YARS1-to-partner and partner-to-YARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formate biosynthetic process grouped by YARS1-low versus YARS1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS1→partner) and Y-score (partner→YARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Formate biosynthetic process →	+0.142	+1.337	<.001	<.001	3	12
PANCREAS	tRNA transport →	+0.098	+1.029	<.001	<.001	3	11
PANCREAS	L-amino acid biosynthetic process →	+0.138	+1.208	.001	<.001	3	11
LARGE_INTESTINE	RISC complex assembly →	+0.081	+0.632	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Serine family amino acid biosynthetic process →	+0.179	+0.750	<.001	<.001	3	10
BONE	Metaphase/anaphase transition of cell cycle →	+0.206	+0.812	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,176 associations by consensus.

Formate biosynthetic process by YARS1 expression — PANCREAS

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