YARS1

Across TCGA cell cohorts, YARS1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible YARS1-associated genes across cancer lineages are OR4F4, C1orf185, and OR10K2. Each is linked with YARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YARS1-to-partner and partner-to-YARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by YARS1-low versus YARS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YARS1→partner) and Y-score (partner→YARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.020	+4.273	<.001	.006	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.063	+4.887	<.001	.009	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR4F4 by YARS1 expression — LARGE_INTESTINE

Explore this box plot interactively →