YAP1

Across TCGA pan-cancer cohorts, YAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated YAP1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher YAP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated YAP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where YAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.859	0.497	.003	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	OS	Median	III,IV	1.000	0.806	.032	4	view →
GBM	DFS	Quartile	All	0.546	0.833	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

YAP1–CCRCC (OS)

Open the CCRCC breakdown →