YAP1

Across TCGA patient cohorts, YAP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,551 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible YAP1-associated proteins across cancer lineages are YAP1_S164, TNKS1BP1, and TRIP6. Each is linked with YAP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both YAP1-to-partner and partner-to-YAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, YAP1 versus YAP1_S164 in GBM, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (YAP1→partner) and Y-score (partner→YAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YAP1_S164 →	+0.841	+1.049	<.001	<.001	3	6
GBM	TNKS1BP1 →	+0.250	+0.799	.002	<.001	3	5
GBM	TRIP6 →	+0.391	+0.952	<.001	<.001	3	5
BRCA	PTK7 →	+0.354	+0.714	.003	<.001	3	5
HNSC	YAP1_S61 →	+0.908	+1.016	<.001	.002	2	6
COAD	RAI14 →	+0.341	+0.552	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,551 associations by consensus.

YAP1 vs YAP1_S164 — GBM

Explore this scatter interactively →