YAP1

Across TCGA cell cohorts, YAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YAP1-associated GO terms across cancer lineages are Positive regulation of protein K48-linked ubiquitination, Regulation of protein K48-linked ubiquitination, and Regulation of focal adhesion assembly. Each is linked with YAP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both YAP1-to-partner and partner-to-YAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein K48-linked ubiquitination grouped by YAP1-low versus YAP1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YAP1→partner) and Y-score (partner→YAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of protein K48-linked ubiquitination →	+0.158	+0.900	.001	.001	3	15
BREAST	Regulation of protein K48-linked ubiquitination →	+0.165	+1.667	<.001	<.001	3	13
BONE	Regulation of focal adhesion assembly →	+0.195	+2.197	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction assembly →	+0.195	+2.197	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction organization →	+0.126	+1.692	<.001	<.001	3	11
BONE	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.113	+1.850	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,538 associations by consensus.

Positive regulation of protein K48-linked ubiquitination by YAP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →