YAF2

Across TCGA pan-cancer cohorts, YAF2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated YAF2 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher YAF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated YAF2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where YAF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.386	.002	48	view →
LUAD	OS	Median	II,III,IV	0.886	1.000	.009	21	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.757	.011	10	view →
PDAC	DFS	Median	IV	0.934	0.238	.017	6	view →
LSCC	DFS	Median	All	0.972	0.910	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

YAF2–UCEC (DFS)

Open the UCEC breakdown →