YAF2

Across TCGA patient cohorts, YAF2 mutation is significantly associated with the RNA expression of many other genes, with 2,961 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YAF2-associated genes across cancer lineages are LINC02719, MIR4804, and OR6C74. Each is linked with YAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YAF2-to-partner and partner-to-YAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02719 grouped by YAF2-low versus YAF2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YAF2→partner) and Y-score (partner→YAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02719 →	+0.079	+5.814	<.001	.001	3	2
BLCA	MIR4804 →	+0.733	+4.799	<.001	.003	3	2
BLCA	OR6C74 →	+0.087	+6.484	<.001	<.001	3	2
UCEC	MIR548N →	+0.223	+2.174	.005	.008	3	2
UCEC	HSPE1-MOB4 →	+0.151	+2.332	.001	<.001	3	1
UCEC	SRGAP2D →	+0.264	+3.170	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,961 associations by consensus.

LINC02719 by YAF2 expression — BLCA

Explore this box plot interactively →