YAF2

Across TCGA cell cohorts, YAF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,253 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YAF2-associated GO terms across cancer lineages are Protein modification by small protein removal, Negative regulation of gene expression, epigenetic, and Peptidyl-amino acid modification. Each is linked with YAF2 in more than 10 cancer types. Because this analysis shows association rather than direction, both YAF2-to-partner and partner-to-YAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by YAF2-low versus YAF2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YAF2→partner) and Y-score (partner→YAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Protein modification by small protein removal →	+0.045	+0.640	<.001	<.001	3	10
BONE	Negative regulation of gene expression, epigenetic →	+0.074	+0.698	.004	.002	2	11
STOMACH	Peptidyl-amino acid modification →	+0.030	+0.633	.003	.003	3	10
BONE	Regulation of microtubule-based process →	+0.050	+0.632	<.001	<.001	3	10
BLOOD_Leukemia	Golgi to vacuole transport →	+0.055	+0.420	<.001	<.001	3	10
BLOOD_Myeloma	Regulation of interleukin-6 production →	-0.066	-0.728	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

Protein modification by small protein removal by YAF2 expression — LARGE_INTESTINE

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