XYLT2

Across TCGA patient cohorts, XYLT2 mutation is significantly associated with the RNA expression of many other genes, with 1,963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XYLT2-associated genes across cancer lineages are OR1L1, MIR4749, and COX5BP8. Each is linked with XYLT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XYLT2-to-partner and partner-to-XYLT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by XYLT2-low versus XYLT2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLT2→partner) and Y-score (partner→XYLT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR1L1 →	+0.046	+4.588	<.001	.008	3	2
STAD	MIR4749 →	+0.227	+5.417	<.001	.001	3	2
COAD	COX5BP8 →	+0.277	+4.893	<.001	<.001	3	2
COAD	GAPDHP17 →	+0.080	+4.721	<.001	.004	3	2
COAD	RPS23P4 →	+0.223	+4.145	<.001	.002	3	2
COAD	MTND4LP2 →	+0.189	+4.721	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,963 associations by consensus.

OR1L1 by XYLT2 expression — BLCA

Explore this box plot interactively →