XYLT2

Across TCGA cell cohorts, XYLT2 mutation is significantly associated with the RNA expression of many other genes, with 2,021 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XYLT2-associated genes across cancer lineages are CSN1S1, TSGA13, and SEPTIN3. Each is linked with XYLT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XYLT2-to-partner and partner-to-XYLT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN1S1 grouped by XYLT2-low versus XYLT2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLT2→partner) and Y-score (partner→XYLT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSN1S1 →	+0.031	+4.887	<.001	.009	3	2
OVARY	TSGA13 →	+0.024	+3.841	<.001	.003	3	2
LARGE_INTESTINE	SEPTIN3 →	+0.964	+2.216	.002	<.001	3	2
LARGE_INTESTINE	PPP6R2 →	+0.567	+2.216	.001	<.001	3	2
LARGE_INTESTINE	CCP110 →	+0.680	+2.700	<.001	.001	3	2
LARGE_INTESTINE	PPP3CB →	+0.372	+1.721	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,021 associations by consensus.

CSN1S1 by XYLT2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →