XYLT1

Across TCGA patient cohorts, XYLT1 mutation is significantly associated with the RNA expression of many other genes, with 4,442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XYLT1-associated genes across cancer lineages are RNU1-35P, POLE2, and EIF2B1. Each is linked with XYLT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XYLT1-to-partner and partner-to-XYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-35P grouped by XYLT1-low versus XYLT1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLT1→partner) and Y-score (partner→XYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-35P →	+0.567	+3.231	<.001	.005	3	4
UCEC	POLE2 →	+0.412	+1.343	<.001	<.001	3	3
UCEC	EIF2B1 →	+0.235	+1.979	.001	<.001	3	3
LUAD	DDX55 →	+0.332	+2.113	.001	.003	3	3
UCEC	COQ3 →	+0.366	+1.526	<.001	.001	3	3
SKCM	RBM17 →	+0.330	+1.533	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

RNU1-35P by XYLT1 expression — STAD

Explore this box plot interactively →