XYLT1

Across TCGA cell cohorts, XYLT1 mutation is significantly associated with the RNA expression of many other genes, with 1,285 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XYLT1-associated genes across cancer lineages are TEX53, COMMD2, and SDHB. Each is linked with XYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XYLT1-to-partner and partner-to-XYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX53 grouped by XYLT1-low versus XYLT1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLT1→partner) and Y-score (partner→XYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TEX53 →	+0.063	+3.169	<.001	.007	3	2
BLOOD_Leukemia	COMMD2 →	+0.561	+3.259	.009	.006	3	2
BLOOD_Leukemia	SDHB →	+0.437	+3.318	.002	.005	3	2
BLOOD_Leukemia	THUMPD3 →	+0.434	+3.199	.006	.007	3	2
BLOOD_Leukemia	ALKBH4 →	+0.511	+3.115	.001	.009	3	2
BLOOD_Leukemia	RNF123 →	+0.532	+3.199	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,285 associations by consensus.

TEX53 by XYLT1 expression — SOFT_TISSUE

Explore this box plot interactively →