XXYLT1

Across TCGA patient cohorts, XXYLT1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XXYLT1-associated genes across cancer lineages are Ku80, ERK2, and FOXO3a_pS318_S321. Each is linked with XXYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XXYLT1-to-partner and partner-to-XXYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by XXYLT1-low versus XXYLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XXYLT1→partner) and Y-score (partner→XXYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.302	+2.183	.014	.035	3	2
UCEC	ERK2 →	+0.252	+3.321	.012	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.148	-2.990	.023	.036	3	1
UCEC	mTOR_pS2448 →	-0.214	-3.150	.006	.019	3	1
UCEC	p62 Lck ligand →	+0.514	+3.009	.002	.019	3	1
UCEC	PDCD4 →	-0.545	-3.321	.027	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by XXYLT1 expression — UCEC

Explore this box plot interactively →