XRRA1

Across TCGA patient cohorts, XRRA1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRRA1-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and Mre11. Each is linked with XRRA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XRRA1-to-partner and partner-to-XRRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by XRRA1-low versus XRRA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRRA1→partner) and Y-score (partner→XRRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.583	+2.242	.005	.005	3	4
UCEC	eEF2 →	+0.357	+2.000	.004	.030	3	2
UCEC	Mre11 →	-0.061	-1.362	.045	.037	3	2
UCEC	PDCD4 →	-0.498	-1.662	.002	.011	3	2
UCEC	Rictor_pT1135 →	-0.092	-2.807	.010	.003	3	2
UCEC	Bax →	+0.188	+1.662	.026	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by XRRA1 expression — UCEC

Explore this box plot interactively →