XRN1

Across TCGA pan-cancer cohorts, XRN1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated XRN1 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XRN1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated XRN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BRCA, and THCA are the cancer types where XRN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.848	0.623	.002	36	view →
BRCA	DFS	Median	All	0.645	0.904	<.001	30	view →
THCA	DFS	Median	All	0.038	0.841	<.001	18	view →
DLBC	OS	Median	All	0.054	0.842	<.001	6	view →
ESCA	DFS	Median	All	0.167	0.506	.046	3	view →
BLCA	OS	Median	All	1.000	0.358	.048	2	view →
SKCM	DFS	Median	II,III,IV	0.945	0.678	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

XRN1–UCEC (DFS)

Open the UCEC breakdown →