XRN1

Across TCGA pan-cancer cohorts, XRN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XRN1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher XRN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated XRN1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where XRN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	1.000	0.844	.001	38	view →
PDAC	OS	Tertile	II,III,IV	0.705	0.913	.001	35	view →
CCRCC	DFS	Median	III,IV	0.518	0.873	.002	28	view →
COAD	DFS	Quartile	All	0.900	1.000	.027	18	view →
GBM	DFS	Quartile	All	0.549	0.220	.013	5	view →
LSCC	DFS	Tertile	All	0.970	0.952	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XRN1–LUAD (DFS)

Open the LUAD breakdown →