XRN1

Across TCGA pan-cancer cohorts, XRN1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of XRN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where XRN1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types XRN1 is over-expressed in tumor.

HNSC, CCRCC, and COAD are the cancer types where XRN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XRN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.319	<.001	11	view →
CCRCC	Female	II,III,IV	+0.293	<.001	11	view →
COAD	Male	All	+0.221	<.001	10	view →
LSCC	Female	All	+0.380	<.001	9	view →
LUAD	Male	All	+0.167	<.001	7	view →
PDAC	All	II,III,IV	+0.103	.014	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

XRN1–HNSC

Open the HNSC breakdown →