XRN1

Across TCGA patient cohorts, XRN1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRN1-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and eEF2. Each is linked with XRN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XRN1-to-partner and partner-to-XRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by XRN1-low versus XRN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN1→partner) and Y-score (partner→XRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.019	<.001	.001	3	4
COAD	FASN →	+0.545	+3.008	.007	.019	2	4
UCEC	eEF2 →	+0.233	+1.125	.031	.033	3	3
UCEC	eIF4E →	+0.165	+1.530	.009	.004	3	3
UCEC	EGFR_pY1068 →	-0.295	-1.999	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.141	-2.234	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by XRN1 expression — UCEC

Explore this box plot interactively →