XRN1

Across TCGA cell cohorts, XRN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,909 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XRN1-associated GO terms across cancer lineages are Peptidyl-serine modification, Peptidyl-serine phosphorylation, and Negative regulation of macroautophagy. Each is linked with XRN1 in more than 18 cancer types. Because this analysis shows association rather than direction, both XRN1-to-partner and partner-to-XRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-serine modification grouped by XRN1-low versus XRN1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN1→partner) and Y-score (partner→XRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Peptidyl-serine modification →	+0.106	+1.038	<.001	<.001	3	19
KIDNEY	Peptidyl-serine phosphorylation →	+0.107	+1.038	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Negative regulation of macroautophagy →	+0.077	+0.913	<.001	.002	3	18
LUNG_NSCLC_LUSC	Regulation of organelle assembly →	+0.060	+0.820	<.001	.005	3	18
STOMACH	Protein modification by small protein removal →	+0.059	+1.087	.002	<.001	3	17
STOMACH	Regulation of cellular response to heat →	+0.126	+0.959	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,909 associations by consensus.

Peptidyl-serine modification by XRN1 expression — KIDNEY

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