XRN1

Across TCGA cell cohorts, XRN1 mutation is significantly associated with the RNA expression of many other genes, with 766 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XRN1-associated genes across cancer lineages are R3HCC1, PIGL, and HDDC2. Each is linked with XRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRN1-to-partner and partner-to-XRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HCC1 grouped by XRN1-low versus XRN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN1→partner) and Y-score (partner→XRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	R3HCC1 →	+0.660	+2.743	.004	.001	3	2
LARGE_INTESTINE	PIGL →	+0.663	+3.459	.003	.001	3	2
LARGE_INTESTINE	HDDC2 →	+0.597	+2.043	.003	.008	3	2
LARGE_INTESTINE	BNIP1 →	+0.394	+3.237	.002	.003	3	2
LARGE_INTESTINE	GLT8D1 →	+0.437	+2.043	<.001	.008	3	2
LARGE_INTESTINE	WDR87 →	+0.012	+2.131	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 766 associations by consensus.

R3HCC1 by XRN1 expression — LARGE_INTESTINE

Explore this box plot interactively →