Across TCGA patient cohorts, XRCC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,791 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XRCC6-associated proteins across cancer lineages are ATXN10, MCM3, and XRCC5. Each is linked with XRCC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both XRCC6-to-partner and partner-to-XRCC6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC6→partner) and Y-score (partner→XRCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATXN10 →	+0.381	+0.461	<.001	<.001	3	8
GBM	MCM3 →	+0.559	+0.254	.002	.001	3	7
OV	XRCC5 →	+0.299	+0.601	<.001	<.001	3	7
LSCC	RANBP1 →	+0.390	+0.464	<.001	<.001	3	6
OV	RANGAP1 →	+0.284	+0.496	.001	.001	2	7
BRCA	CCDC134 →	+0.571	+0.527	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,791 associations by consensus.

Exploration

XRCC6 survival (RNA) · tumor vs normal (RNA) · all XRCC6 data types