Across TCGA patient cohorts, XRCC6 protein abundance is significantly associated with the RNA expression of many other genes, with 14,222 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XRCC6-associated genes across cancer lineages are MBTD1, FARSB, and EIF3L. Each is linked with XRCC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both XRCC6-to-partner and partner-to-XRCC6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC6→partner) and Y-score (partner→XRCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MBTD1 →	+0.525	+0.133	<.001	.005	3	8
HNSC	FARSB →	+0.645	+0.158	<.001	<.001	3	8
OV	EIF3L →	+1.011	+0.396	<.001	<.001	3	7
HNSC	SAMM50 →	+0.603	+0.166	<.001	.001	3	7
OV	EIF3D →	+0.711	+0.365	<.001	<.001	3	7
HNSC	PHF5A →	+0.781	+0.178	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,222 associations by consensus.

Exploration

XRCC6 survival (RNA) · tumor vs normal (RNA) · all XRCC6 data types