Across TCGA patient cohorts, XRCC6 protein abundance is significantly associated with the protein abundance of many other proteins, with 24,205 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XRCC6-associated proteins across cancer lineages are PRPF31, PRPF4, and PRPF6. Each is linked with XRCC6 in more than 9 cancer types. Because this analysis shows association rather than direction, both XRCC6-to-partner and partner-to-XRCC6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC6→partner) and Y-score (partner→XRCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF31 →	+0.369	+0.390	<.001	<.001	3	10
GBM	PRPF4 →	+0.337	+0.381	<.001	<.001	3	10
GBM	PRPF6 →	+0.374	+0.370	<.001	<.001	3	10
GBM	RAD21 →	+0.311	+0.342	<.001	<.001	3	10
GBM	ZFR →	+0.268	+0.377	<.001	<.001	3	10
LSCC	NONO →	+0.222	+0.252	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,205 associations by consensus.

Exploration

XRCC6 survival (RNA) · tumor vs normal (RNA) · all XRCC6 data types