Across TCGA patient cohorts, XRCC6 mutation is significantly associated with the RNA expression of many other genes, with 1,577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC6-associated genes across cancer lineages are SNORD115-8, VENTXP7, and OR51K1P. Each is linked with XRCC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC6-to-partner and partner-to-XRCC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC6→partner) and Y-score (partner→XRCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	SNORD115-8 →	+0.482	+7.939	<.001	.008	3	1
COAD	VENTXP7 →	+0.227	+5.283	<.001	.006	3	1
COAD	OR51K1P →	+0.320	+5.212	<.001	.007	3	1
COAD	RNU6-709P →	+0.992	+7.142	<.001	<.001	3	1
COAD	RN7SL835P →	+0.527	+5.283	<.001	.006	3	1
UCEC	POM121C →	+0.379	+2.609	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,577 associations by consensus.

Exploration

XRCC6 survival (RNA) · tumor vs normal (RNA) · all XRCC6 data types