Across TCGA cell cohorts, XRCC6 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XRCC6-associated genes across cancer lineages are HTR1E, TTLL8, and TBC1D21. Each is linked with XRCC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC6-to-partner and partner-to-XRCC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC6→partner) and Y-score (partner→XRCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR1E →	+0.036	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TTLL8 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	REG1B →	+2.134	+4.196	.002	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR52H1 →	+0.033	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

XRCC6 survival (RNA) · tumor vs normal (RNA) · all XRCC6 data types