XRCC5

Across TCGA pan-cancer cohorts, XRCC5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XRCC5 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher XRCC5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated XRCC5 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where XRCC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.882	.021	36	view →
HNSC	DFS	Quartile	II,III,IV	0.876	1.000	.003	36	view →
LSCC	OS	Tertile	III,IV	0.443	0.918	.022	6	view →
UCEC	DFS	Median	III,IV	0.460	0.889	.044	6	view →
PDAC	DFS	Tertile	All	0.903	0.716	.022	2	view →
CCRCC	OS	Median	III,IV	0.886	0.615	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XRCC5–COAD (DFS)

Open the COAD breakdown →