XRCC5

Across TCGA pan-cancer cohorts, XRCC5 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of XRCC5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where XRCC5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types XRCC5 is over-expressed in tumor.

COAD, LSCC, and CCRCC are the cancer types where XRCC5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XRCC5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.406	<.001	10	view →
LSCC	Female	II,III,IV	+0.301	<.001	9	view →
CCRCC	Male	All	+0.171	<.001	8	view →
PDAC	Male	All	+0.310	<.001	7	view →
LUAD	Male	All	+0.141	<.001	6	view →
HNSC	Male	II,III,IV	+0.135	<.001	6	view →
OV	All	All	+0.484	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

XRCC5–COAD

Open the COAD breakdown →