XRCC5

Across TCGA patient cohorts, XRCC5 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,498 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XRCC5-associated proteins across cancer lineages are XRCC6, NONO, and NOP58. Each is linked with XRCC5 in more than 9 cancer types. Because this analysis shows association rather than direction, both XRCC5-to-partner and partner-to-XRCC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XRCC5 versus XRCC6 in GBM, with a Pearson correlation of 0.94.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC5→partner) and Y-score (partner→XRCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XRCC6 →	+0.439	+0.404	<.001	<.001	3	10
UCEC	NONO →	+0.222	+0.234	<.001	<.001	3	10
OV	NOP58 →	+0.415	+0.211	<.001	<.001	3	10
BRCA	NUP133 →	+0.188	+0.266	<.001	<.001	3	10
GBM	NXF1 →	+0.318	+0.315	<.001	<.001	3	10
GBM	POLDIP3 →	+0.408	+0.342	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,498 associations by consensus.

XRCC5 vs XRCC6 — GBM

Explore this scatter interactively →