XRCC5

Across TCGA cell cohorts, XRCC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,631 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XRCC5-associated GO terms across cancer lineages are DNA-templated DNA replication, DNA-templated DNA replication maintenance of fidelity, and Mitotic sister chromatid cohesion. Each is linked with XRCC5 in more than 19 cancer types. Because this analysis shows association rather than direction, both XRCC5-to-partner and partner-to-XRCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by XRCC5-low versus XRCC5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC5→partner) and Y-score (partner→XRCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.163	+1.378	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.136	+1.026	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.134	+1.282	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.192	+1.272	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.143	+1.405	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.147	+1.328	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,631 associations by consensus.

DNA-templated DNA replication by XRCC5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →