XRCC4

Across TCGA pan-cancer cohorts, XRCC4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated XRCC4 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher XRCC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated XRCC4 expression acts as an unfavorable survival marker.

KICH, LUSC, and LUAD are the cancer types where XRCC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
LUAD	OS	Median	All	0.238	0.697	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

XRCC4–KICH (DFS)

Open the KICH breakdown →