XRCC3

Across TCGA pan-cancer cohorts, XRCC3 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of XRCC3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where XRCC3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types XRCC3 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LSCC and COAD are the cancer types where XRCC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XRCC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	+1.055	<.001	7	view →
COAD	All	All	−2.055	.031	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

XRCC3–LSCC

Open the LSCC breakdown →