XRCC3

Across TCGA patient cohorts, XRCC3 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC3-associated genes across cancer lineages are MIR6090, LINC01848, and PRAMEF28P. Each is linked with XRCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC3-to-partner and partner-to-XRCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6090 grouped by XRCC3-low versus XRCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC3→partner) and Y-score (partner→XRCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6090 →	+0.400	+3.136	<.001	.008	3	2
UCEC	LINC01848 →	+0.124	+3.132	<.001	.003	3	2
UCEC	PRAMEF28P →	+0.064	+3.329	.004	.005	3	1
CESC	OR5D3P →	+0.036	+5.837	<.001	.001	3	1
CESC	RNA5SP432 →	+0.255	+4.539	.001	.008	3	1
CESC	UBE2V2P1 →	+0.198	+4.364	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

MIR6090 by XRCC3 expression — UCEC

Explore this box plot interactively →