XRCC3

Across TCGA cell cohorts, XRCC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,869 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible XRCC3-associated GO terms across cancer lineages are DNA replication checkpoint signaling, DNA replication, and DNA-templated DNA replication. Each is linked with XRCC3 in more than 19 cancer types. Because this analysis shows association rather than direction, both XRCC3-to-partner and partner-to-XRCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by XRCC3-low versus XRCC3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC3→partner) and Y-score (partner→XRCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA replication checkpoint signaling →	+0.216	+1.662	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.141	+1.919	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.160	+1.920	<.001	<.001	3	19
BONE	Double-strand break repair →	+0.088	+1.202	<.001	<.001	3	19
OESOPHAGUS	DNA recombination →	+0.107	+1.502	<.001	.002	3	19
BONE	Double-strand break repair via homologous recombination →	+0.100	+1.196	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,869 associations by consensus.

DNA replication checkpoint signaling by XRCC3 expression — OESOPHAGUS

Explore this box plot interactively →