XRCC3

Across TCGA cell cohorts, XRCC3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XRCC3-associated genes across cancer lineages are IZUMO1R, FCN2, and HSFY2. Each is linked with XRCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC3-to-partner and partner-to-XRCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO1R grouped by XRCC3-low versus XRCC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC3→partner) and Y-score (partner→XRCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IZUMO1R →	+0.141	+5.539	<.001	.003	3	1
LARGE_INTESTINE	FCN2 →	+0.052	+5.415	<.001	.004	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IZUMO1R by XRCC3 expression — BLOOD_Leukemia

Explore this box plot interactively →