Across TCGA patient cohorts, XRCC2 protein abundance is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XRCC2-associated genes across cancer lineages are SHC2, SWAP70, and LDHA. Each is linked with XRCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC2-to-partner and partner-to-XRCC2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC2→partner) and Y-score (partner→XRCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SHC2 →	-0.707	-0.727	.007	.002	3	1
HNSC	SWAP70 →	+0.468	+0.875	.002	.005	3	1
HNSC	LDHA →	+0.967	+0.875	.001	.005	3	1
HNSC	THRB →	+1.412	+0.672	.006	.004	3	1
HNSC	GFRA1 →	-0.994	-0.607	.003	.006	3	1
HNSC	CCDC58 →	+0.607	+1.132	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

Exploration

XRCC2 survival (RNA) · tumor vs normal (RNA) · all XRCC2 data types