XRCC2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, XRCC2 mutation is significantly associated with the RNA expression of many other genes, with 2,340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC2-associated genes across cancer lineages are CYP4F44P, RNA5SP411, and MIR508. Each is linked with XRCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC2-to-partner and partner-to-XRCC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC2→partner) and Y-score (partner→XRCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCACYP4F44P →+0.087+5.455<.001.00132
UCECRNA5SP411 →+1.078+2.031<.001.00732
LGGMIR508 →+0.278+7.977<.001.00732
COADMIR4729 →+1.454+5.374<.001.00132
COADMIR3978 →+0.857+5.251<.001.00332
UCECUSP9YP2 →+0.020+5.258<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,340 associations by consensus.

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