Across TCGA patient cohorts, XRCC2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC2-associated genes across cancer lineages are ATM, A-Raf_pS299, and Heregulin. Each is linked with XRCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC2-to-partner and partner-to-XRCC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC2→partner) and Y-score (partner→XRCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.427	-2.000	.037	.032	3	2
UCEC	A-Raf_pS299 →	-0.138	-3.321	.010	.010	3	1
UCEC	Heregulin →	-0.146	-2.321	.008	.034	3	1
UCEC	INPP4B →	-0.343	-3.321	.018	.009	3	1
UCEC	p62 Lck ligand →	+0.485	+3.009	<.001	.019	3	1
UCEC	PRAS40_pT246 →	+0.205	+2.013	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

XRCC2 survival (RNA) · tumor vs normal (RNA) · all XRCC2 data types