XRCC1

Across TCGA pan-cancer cohorts, XRCC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated XRCC1 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher XRCC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated XRCC1 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where XRCC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.022	24	view →
HNSC	DFS	Median	III,IV	0.917	0.984	.036	15	view →
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	14	view →
LUAD	DFS	Tertile	III,IV	0.871	0.285	.008	8	view →
PDAC	DFS	Median	III,IV	0.400	0.663	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

XRCC1–COAD (DFS)

Open the COAD breakdown →