Across TCGA patient cohorts, XPOT protein abundance is significantly associated with the RNA expression of many other genes, with 16,995 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XPOT-associated genes across cancer lineages are CENPA, MMRN1, and ABCA8. Each is linked with XPOT in more than 7 cancer types. Because this analysis shows association rather than direction, both XPOT-to-partner and partner-to-XPOT results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPOT→partner) and Y-score (partner→XPOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPA →	+0.960	+0.282	<.001	<.001	3	7
BRCA	MMRN1 →	-1.310	-0.327	<.001	<.001	3	7
BRCA	ABCA8 →	-1.249	-0.337	<.001	<.001	3	7
BRCA	GNA14 →	-0.878	-0.190	<.001	<.001	3	7
UCEC	RACGAP1 →	+0.823	+0.261	<.001	<.001	3	7
LSCC	PA2G4 →	+0.670	+0.475	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,995 associations by consensus.

Exploration

XPOT survival (RNA) · tumor vs normal (RNA) · all XPOT data types