XPOT

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, XPOT mutation is significantly associated with the RNA expression of many other genes, with 3,757 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPOT-associated genes across cancer lineages are RPS29P31, LINC00489, and LINC01758. Each is linked with XPOT in more than 2 cancer types. Because this analysis shows association rather than direction, both XPOT-to-partner and partner-to-XPOT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPOT→partner) and Y-score (partner→XPOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
READRPS29P31 →+0.285+5.653.002.00333
HNSCLINC00489 →+0.049+4.526<.001.00732
HNSCLINC01758 →+0.110+5.440.009<.00132
LGGRNU6-383P →+0.368+7.977<.001.00732
BRCAMIR892C →+0.218+7.057<.001.00932
BRCALINC02399 →+0.139+5.587.003<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Exploration