XPOT

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, XPOT mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPOT-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and PDCD4. Each is linked with XPOT in more than 1 cancer types. Because this analysis shows association rather than direction, both XPOT-to-partner and partner-to-XPOT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPOT→partner) and Y-score (partner→XPOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEGFR_pY1068 →-0.178-1.584.034.00932
UCECmTOR_pS2448 →-0.138-3.687.005.00132
UCECPDCD4 →-0.543-1.584<.001.00932
UCECXBP1 →-0.128-1.415.006.04332
UCECCyclin-B1 →+0.704+3.906<.001<.00132
UCECA-Raf_pS299 →-0.113-2.000.004.00931
Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration