XPO7

Across TCGA pan-cancer cohorts, XPO7 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated XPO7 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XPO7 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated XPO7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and ACC are the cancer types where XPO7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.505	.014	28	view →
COAD	OS	Median	II,III,IV	0.125	0.785	.001	15	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
LIHC	OS	Median	II,III,IV	0.195	0.715	.009	12	view →
SKCM	DFS	Median	III,IV	0.012	0.597	<.001	9	view →
ESCA	OS	Median	All	0.095	0.681	<.001	8	view →
LUSC	DFS	Median	All	0.174	0.510	.031	5	view →
BRCA	OS	Median	All	0.199	0.580	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

XPO7–UCEC (OS)

Open the UCEC breakdown →