XPO7

Across TCGA patient cohorts, XPO7 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO7-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and PAI-1. Each is linked with XPO7 in more than 2 cancer types. Because this analysis shows association rather than direction, both XPO7-to-partner and partner-to-XPO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by XPO7-low versus XPO7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO7→partner) and Y-score (partner→XPO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.596	+2.107	.001	.002	3	3
UCEC	mTOR_pS2448 →	-0.123	-1.986	.007	.008	3	2
UCEC	PAI-1 →	+0.255	+1.247	.015	.041	3	2
UCEC	eIF4E →	+0.231	+1.947	<.001	<.001	3	1
UCEC	ERK2 →	+0.166	+1.874	.004	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.100	-1.990	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by XPO7 expression — UCEC

Explore this box plot interactively →