XPO7

Across TCGA cell cohorts, XPO7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,451 significant associations in total. BONE shows the largest number of these associations.

The most reproducible XPO7-associated GO terms across cancer lineages are Positive regulation of telomere capping, Nuclear transport, and Negative regulation of sister chromatid cohesion. Each is linked with XPO7 in more than 17 cancer types. Because this analysis shows association rather than direction, both XPO7-to-partner and partner-to-XPO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere capping grouped by XPO7-low versus XPO7-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO7→partner) and Y-score (partner→XPO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of telomere capping →	+0.133	+0.884	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.083	+1.140	<.001	<.001	3	16
LUNG_SCLC	Negative regulation of sister chromatid cohesion →	+0.160	+0.861	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.083	+1.190	<.001	<.001	3	16
BONE	Protein-DNA complex organization →	+0.106	+1.154	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.090	+1.219	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,451 associations by consensus.

Positive regulation of telomere capping by XPO7 expression — KIDNEY

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