XPO7

Across TCGA cell cohorts, XPO7 mutation is significantly associated with the RNA expression of many other genes, with 1,371 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPO7-associated genes across cancer lineages are FBXW10, ELOA3CP, and MUC7. Each is linked with XPO7 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO7-to-partner and partner-to-XPO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by XPO7-low versus XPO7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO7→partner) and Y-score (partner→XPO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.197	+2.916	<.001	<.001	3	2
LARGE_INTESTINE	ELOA3CP →	+0.083	+1.936	.003	.009	3	2
BLOOD_Lymphoma	MUC7 →	+0.020	+4.191	<.001	.007	3	2
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,371 associations by consensus.

FBXW10 by XPO7 expression — LARGE_INTESTINE

Explore this box plot interactively →