XPO6

Across TCGA patient cohorts, XPO6 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO6-associated genes across cancer lineages are Cyclin-E2, FASN, and eEF2. Each is linked with XPO6 in more than 2 cancer types. Because this analysis shows association rather than direction, both XPO6-to-partner and partner-to-XPO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by XPO6-low versus XPO6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO6→partner) and Y-score (partner→XPO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.121	+2.097	.017	.003	3	3
STAD	FASN →	+0.397	+3.015	.042	.018	3	2
UCEC	eEF2 →	+0.239	+1.807	.027	.024	3	2
UCEC	ACC1 →	+0.299	+1.598	.006	.019	3	2
UCEC	JNK2 →	+0.188	+2.441	.001	.001	3	2
UCEC	Ku80 →	+0.264	+1.768	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-E2 by XPO6 expression — UCEC

Explore this box plot interactively →