XPO6

Across TCGA cell cohorts, XPO6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,590 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XPO6-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Negative regulation of autophagosome maturation, and Positive regulation of mitotic cytokinesis. Each is linked with XPO6 in more than 13 cancer types. Because this analysis shows association rather than direction, both XPO6-to-partner and partner-to-XPO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by XPO6-low versus XPO6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO6→partner) and Y-score (partner→XPO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of cilium assembly →	+0.075	+0.898	<.001	<.001	3	14
BREAST	Negative regulation of autophagosome maturation →	+0.112	+0.766	<.001	<.001	3	13
BREAST	Positive regulation of mitotic cytokinesis →	+0.159	+0.792	.002	<.001	3	13
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.130	+0.506	.004	.002	3	13
BREAST	RNA export from nucleus →	+0.082	+0.607	.006	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.103	+1.045	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,590 associations by consensus.

Negative regulation of cilium assembly by XPO6 expression — BREAST

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