XPO6

Across TCGA cell cohorts, XPO6 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPO6-associated genes across cancer lineages are OPN1LW, IL9, and CRYAA. Each is linked with XPO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO6-to-partner and partner-to-XPO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1LW grouped by XPO6-low versus XPO6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO6→partner) and Y-score (partner→XPO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OPN1LW →	+0.059	+5.169	<.001	.005	3	1
BREAST	IL9 →	+0.053	+5.781	<.001	.001	3	1
BLOOD_Leukemia	CRYAA →	+0.049	+4.705	.006	.003	3	1
BLOOD_Leukemia	LYPD2 →	+0.123	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+6.554	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR2B3 →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

OPN1LW by XPO6 expression — BREAST

Explore this box plot interactively →